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CRY2 is associated with depression
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2010 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 5, no 2, article id e9407Article in journal (Refereed) Published
Abstract [en]

Background: Abnormalities in the circadian clockwork often characterize patients with major depressive and bipolar disorders. Circadian clock genes are targets of interest in these patients. CRY2 is a circadian gene that participates in regulation of the evening oscillator. This is of interest in mood disorders where a lack of switch from evening to morning oscillators has been postulated.

Principal Findings: We observed a marked diurnal variation in human CRY2 mRNA levels from peripheral blood mononuclear cells and a significant up-regulation (P = 0.020) following one-night total sleep deprivation, a known antidepressant. In depressed bipolar patients, levels of CRY2 mRNA were decreased (P = 0.029) and a complete lack of increase was observed following sleep deprivation. To investigate a possible genetic contribution, we undertook SNP genotyping of the CRY2 gene in two independent population-based samples from Sweden (118 cases and 1011 controls) and Finland (86 cases and 1096 controls). The CRY2 gene was significantly associated with winter depression in both samples (haplotype analysis in Swedish and Finnish samples: OR = 1.8, P = 0.0059 and OR = 1.8, P = 0.00044, respectively).

Conclusions: We propose that a CRY2 locus is associated with vulnerability for depression, and that mechanisms of action involve dysregulation of CRY2 expression.

Place, publisher, year, edition, pages
Public Library of Science , 2010. Vol. 5, no 2, article id e9407
Keywords [en]
seasonal affective-disorder, single-nucleotide polymorphisms, convergent functional genomics; blue-light photoreceptors; rest-activity disturbances; bipolar-i-disorder; circadian-clock, suprachiasmatic nucleus, candidate genes, melatonin suppression
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-41000DOI: 10.1371/journal.pone.0009407ISI: 000274924200027PubMedID: 20195522OAI: oai:DiVA.org:umu-41000DiVA, id: diva2:404137
Funder
Swedish Research Council, 2005-6245Swedish Research Council, 2006-4670Stockholm County CouncilAvailable from: 2011-03-16 Created: 2011-03-16 Last updated: 2019-01-31Bibliographically approved

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Adolfsson, Rolf

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