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Hyperferritinemia is associated with low incidence of graft versus host disease, high relapse rate, and impaired survival in patients with blood disorders receiving allogeneic hematopoietic stem cell grafts.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology. (Department of Hematology, Cancer Centre, University Hospital, 90185 Umea, Sweden)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology. (Hematology, Department of Radiation Sciences)
Department of Hematology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Centre of Allogeneic Stem Cell Transplantation at Huddinge, Karolinska Institutet, Stockholm, Sweden.
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2011 (English)In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 28, no 2, 552-558 p.Article in journal (Refereed) Published
Abstract [en]

High pre-transplantation serum ferritin levels have been reported to be associated with impaired survival post-transplantation in patients with acute myeloid leukemia or myelodysplastic syndrome. We performed a retrospective study of 309 patients who underwent allogeneic hematopoietic stem cell transplantation at two transplantation centers. The aim was to determine the effect of pre-transplantation hyperferritinemia on survival, graft versus host disease, and relapse. In both univariate and multivariate analysis, elevated ferritin levels were significantly associated with shorter overall and relapse-free survival times and increased relapse rate, but lower risk of chronic graft versus host disease. Elevated ferritin levels were not associated with non-relapse mortality. We hypothesize that ferritin may exert an immunosuppressive effect, reducing graft versus host disease and graft versus leukemia effects, resulting in increased risk of relapse and impaired survival.

Place, publisher, year, edition, pages
2011. Vol. 28, no 2, 552-558 p.
Keyword [en]
Ferritin, Graft versus host disease, Relapse, Survival, Immunosuppressive
National Category
Cancer and Oncology
Research subject
URN: urn:nbn:se:umu:diva-41026DOI: 10.1007/s12032-010-9496-1PubMedID: 20393815OAI: diva2:404250
Available from: 2011-03-16 Created: 2011-03-16 Last updated: 2012-11-12Bibliographically approved

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