Hyperferritinemia is associated with low incidence of graft versus host disease, high relapse rate, and impaired survival in patients with blood disorders receiving allogeneic hematopoietic stem cell grafts.
2011 (English)In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 28, no 2, 552-558 p.Article in journal (Refereed) Published
High pre-transplantation serum ferritin levels have been reported to be associated with impaired survival post-transplantation in patients with acute myeloid leukemia or myelodysplastic syndrome. We performed a retrospective study of 309 patients who underwent allogeneic hematopoietic stem cell transplantation at two transplantation centers. The aim was to determine the effect of pre-transplantation hyperferritinemia on survival, graft versus host disease, and relapse. In both univariate and multivariate analysis, elevated ferritin levels were significantly associated with shorter overall and relapse-free survival times and increased relapse rate, but lower risk of chronic graft versus host disease. Elevated ferritin levels were not associated with non-relapse mortality. We hypothesize that ferritin may exert an immunosuppressive effect, reducing graft versus host disease and graft versus leukemia effects, resulting in increased risk of relapse and impaired survival.
Place, publisher, year, edition, pages
2011. Vol. 28, no 2, 552-558 p.
Ferritin, Graft versus host disease, Relapse, Survival, Immunosuppressive
Cancer and Oncology
Research subject Oncology
IdentifiersURN: urn:nbn:se:umu:diva-41026DOI: 10.1007/s12032-010-9496-1PubMedID: 20393815OAI: oai:DiVA.org:umu-41026DiVA: diva2:404250