Change search
ReferencesLink to record
Permanent link

Direct link
Allogeneic haematopoietic stem-cell transplantation with reduced intensity conditioning for advanced stage Hodgkin's lymphoma in Sweden: high incidence of post transplant lymphoproliferative disorder.
Show others and affiliations
2011 (English)In: Bone Marrow Transplantation, ISSN 0268-3369, E-ISSN 1476-5365, Vol. 46, no 6, 870-875 p.Article in journal (Refereed) Published
Abstract [en]

Allogeneic transplantation after reduced intensity conditioning (allo-RIC) is a treatment option for patients with Hodgkin's lymphoma (HL) relapsing after autologous transplantation. In all, 23 adult patients with HL underwent allo-RIC in Sweden between 2000 and 2007. The median number of previous treatment lines was five and 20 patients (87%) were previously autografted. TRM at 100 days and at 1 year was 13 and 22% respectively. Acute GVHD grades II-IV developed in 7 out of 23 patients (30%) and chronic GVHD in 10 out of 20 patients at risk (50%). The OS and EFS at three years was 59 and 27%, respectively. Four patients (17%) developed post transplant lymphoproliferative disease (PTLD) after a median time of 55 days (range 38-95); two of these patients later died. The study confirmed that allo-RIC is feasible, but associated with a substantial relapse rate: only 20% of the patients were still alive 7 years after the transplant. A finding of high incidence of PTLD needs to be confirmed in a larger trial that includes patients with non-HL and CLL.

Place, publisher, year, edition, pages
Nature Publishing Group , 2011. Vol. 46, no 6, 870-875 p.
Keyword [en]
allogeneic, transplantation, Hodgkin's lymphoma, post transplant lymphoproliferative disorder, reduced intensity conditioning
National Category
Clinical Medicine
URN: urn:nbn:se:umu:diva-41028DOI: 10.1038/bmt.2010.238PubMedID: 20956959OAI: diva2:404255
Available from: 2011-03-16 Created: 2011-03-16 Last updated: 2011-10-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wahlin, Anders
By organisation
In the same journal
Bone Marrow Transplantation
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 44 hits
ReferencesLink to record
Permanent link

Direct link