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Effects of blood group antigen-binding adhesin expression during Helicobacter pylori infection of Mongolian gerbils
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Umeå University, Faculty of Medicine, Department of Odontology, Oral Microbiology. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
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2011 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 203, no 5, 726-735 p.Article in journal (Refereed) Published
Abstract [en]

Helicobacter pylori outer membrane proteins, such as the blood group antigen-binding adhesin (BabA), are associated with severe pathological outcomes. However, the in vivo role of BabA during long-term infection is not clear. In this study, Mongolian gerbils were infected with H. pylori and necropsied continuously during 18 months. Bacterial clones were recovered and analyzed for BabA expression, Leb-binding activity, and adhesion to gastric mucosa. BabA expression was completely absent by 6 months post-infection. Loss of BabA expression was attributable to nucleotide changes within the babA gene that resulted in a truncated BabA. In response to the infection, changes in the epithelial glycosylation pattern were observed that were similar to responses observed in humans and monkeys. Furthermore, infections with BabA-expressing and BabA-nonexpressing H. pylori showed no differences in colonization, but infection with the BabA-expressing strain exhibited histological changes and increased inflammatory cell infiltration. This suggests that BabA expression contributes to severe mucosal injury.

Place, publisher, year, edition, pages
2011. Vol. 203, no 5, 726-735 p.
Keyword [en]
outer-membrane proteins; baba; inflammation; activation; attachment; gastritis; gene; oipa
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-41100DOI: 10.1093/infdis/jiq090PubMedID: 21227917OAI: oai:DiVA.org:umu-41100DiVA: diva2:404659
Available from: 2011-03-17 Created: 2011-03-17 Last updated: 2017-12-11Bibliographically approved

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Vallström, AnnaArnqvist, Anna

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Department of Medical Biochemistry and BiophysicsOral MicrobiologyUmeå Centre for Microbial Research (UCMR)
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