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Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction
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2010 (English)In: Cardiovascular Research, ISSN 0008-6363, E-ISSN 1755-3245, Vol. 87, no 4, 618-627 p.Article in journal (Refereed) Published
Abstract [en]

The findings in this study identify potential therapeutics [i.e. N2 peptide or 21G6 F(ab')(2)] that prevent specific IgM binding to ischaemic antigens in the heart, resulting in a significant reduction in cardiac I/R injury.

Place, publisher, year, edition, pages
2010. Vol. 87, no 4, 618-627 p.
Keyword [en]
Myocardial infarction, Peptides, Lymphocytes, Antibodies, Reperfusion
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-41119DOI: 10.1093/cvr/cvq141ISI: 000280904700008PubMedID: 20462867OAI: diva2:404734
Available from: 2011-03-18 Created: 2011-03-18 Last updated: 2011-12-08Bibliographically approved

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Li, Jinan
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Department of Medical Biochemistry and Biophysics
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