Identification of the target self-antigens in reperfusion injury.
2006 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 203, no 1, 141-52 p.Article in journal (Refereed) Published
Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
Place, publisher, year, edition, pages
2006. Vol. 203, no 1, 141-52 p.
IdentifiersURN: urn:nbn:se:umu:diva-41179DOI: 10.1084/jem.20050390PubMedID: 16390934OAI: oai:DiVA.org:umu-41179DiVA: diva2:404852