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Identification of the target self-antigens in reperfusion injury.
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2006 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 203, no 1, 141-52 p.Article in journal (Refereed) Published
Abstract [en]

Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.

Place, publisher, year, edition, pages
2006. Vol. 203, no 1, 141-52 p.
Identifiers
URN: urn:nbn:se:umu:diva-41179DOI: 10.1084/jem.20050390PubMedID: 16390934OAI: oai:DiVA.org:umu-41179DiVA: diva2:404852
Available from: 2011-03-18 Created: 2011-03-18 Last updated: 2011-03-18

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Li, Jinan

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