Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
2010 (English)In: Breast Cancer Research, ISSN 1465-542X, Vol. 12, no 4, R50- p.Article in journal (Refereed) Published
Chromosomes 2p, 6q and 14q are candidate sites for genes contributing together to high breast cancer risk. A polygenic model is supported, suggesting the joint effect of genes in contributing to breast cancer risk to be rather common in non-BRCA1/2 families. For genetic counselling it would seem important to resolve the mode of genetic interaction.
Place, publisher, year, edition, pages
2010. Vol. 12, no 4, R50- p.
wild-type chromosome; ovarian-cancer; susceptibility locus; gene; population; brca1; prevalence; mutations; penetrance; deletions
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-41285DOI: 10.1186/bcr2608ISI: 000285504100006PubMedID: 20637093OAI: oai:DiVA.org:umu-41285DiVA: diva2:405451