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Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
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2010 (English)In: Breast Cancer Research, ISSN 1465-5411, E-ISSN 1465-542X, Vol. 12, no 4, R50- p.Article in journal (Refereed) Published
Abstract [en]

Chromosomes 2p, 6q and 14q are candidate sites for genes contributing together to high breast cancer risk. A polygenic model is supported, suggesting the joint effect of genes in contributing to breast cancer risk to be rather common in non-BRCA1/2 families. For genetic counselling it would seem important to resolve the mode of genetic interaction.

Place, publisher, year, edition, pages
2010. Vol. 12, no 4, R50- p.
Keyword [en]
wild-type chromosome; ovarian-cancer; susceptibility locus; gene; population; brca1; prevalence; mutations; penetrance; deletions
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Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-41285DOI: 10.1186/bcr2608ISI: 000285504100006PubMedID: 20637093OAI: oai:DiVA.org:umu-41285DiVA: diva2:405451
Available from: 2011-03-22 Created: 2011-03-22 Last updated: 2017-12-11Bibliographically approved

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