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Maintenance and manipulation in working memory: Differential ventral and dorsal frontal cortex fMRI activity
Department of Psychology, Stockholm University, Stockholm, Sweden . (Stockholm Brain Institute, China)
Department of Psychology, Stockholm University, Stockholm, Sweden . (Stockholm Brain Institute, China)
Department of Psychology, Stockholm University, Stockholm, Sweden . (Stockholm Brain Institute, China)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
2009 (English)In: Acta Psychologica Sinica, ISSN 0439-755X, Vol. 41, no 11, 1054-1062 p.Article in journal (Refereed) Published
Abstract [en]

A verbal working memory protocol was designed and evaluated on a group of healthy younger adults in preparation for a large-scale functional magnetic resonance (fMRI) study on aging and memory. Letters were presented in two critical conditions: (i) maintenance, in which letters were to be memorized and kept in mind over a four second interval, and (ii) manipulation, in which letters were shifted forward in alphabetical order, and the new order was kept in mind. Analyses of fMRI data showed that the protocol elicited reliable activation in the frontal cortex, with manipulation producing more extensive activation patterns, both in whole-brain analyses and in predefined regions of interest (ROIs). There was also a distinction between dorsal and ventral lateral prefrontal regions, such that manipulation elicited more dorsolateral prefrontal activation. The protocol also elicited activation in various subcortical areas, previously associated with working-memory tasks. It was concluded that this working memory protocol is appropriate for investigating age-related changes in frontal-cortex functioning.

Place, publisher, year, edition, pages
Science Press, 2009. Vol. 41, no 11, 1054-1062 p.
Keyword [en]
Frontal cortex, fMRI, working memory, maintenance, manipulation
National Category
Psychology
Identifiers
URN: urn:nbn:se:umu:diva-41328DOI: 10.3724/SP.J.1041.2009.01054OAI: oai:DiVA.org:umu-41328DiVA: diva2:405641
Available from: 2011-03-23 Created: 2011-03-23 Last updated: 2014-07-18Bibliographically approved

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CiteExportLink to record
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  • apa
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  • de-DE
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