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Muscle spindle composition and distribution in human young masseter and biceps brachii muscles reveal early growth and maturation
Umeå University, Faculty of Medicine, Department of Odontology, Clinical Oral Physiology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
Umeå University, Faculty of Medicine, Department of Odontology, Clinical Oral Physiology.
2011 (English)In: Anatomical Record, ISSN 0003-276X, E-ISSN 1097-0185, Vol. 294, no 4, 683-693 p.Article in journal (Refereed) Published
Abstract [en]

Significant changes in extrafusal fiber type composition take place in the human masseter muscle from young age, 3-7 years, to adulthood, in parallel with jaw-face skeleton growth, changes of dentitions and improvement of jaw functions. As motor and sensory control systems of muscles are interlinked, also the intrafusal fiber population, that is, muscle spindles, should undergo age-related changes in fiber type appearance. To test this hypothesis, we examined muscle spindles in the young masseter muscle and compared the result with previous data on adult masseter spindles. Also muscle spindles in the young biceps brachii muscle were examined. The result showed that muscle spindle composition and distribution were alike in young and adult masseter. As for the adult masseter, young masseter contained exceptionally large muscle spindles, and with the highest spindle density and most complex spindles found in the deep masseter portion. Hence, contrary to our hypothesis, masseter spindles do not undergo major morphological changes between young age and adulthood. Also in the biceps, young spindles were alike adult spindles. Taken together, the results showed that human masseter and biceps muscle spindles are morphologically mature already at young age. We conclude that muscle spindles in the human young masseter and biceps precede the extrafusal fiber population in growth and maturation. This in turn suggests early reflex control and proprioceptive demands in learning and maturation of jaw motor skills. Similarly, well-developed muscle spindles in young biceps reflect early need of reflex control in learning and performing arm motor behavior.

Place, publisher, year, edition, pages
Wiley-Liss, Inc. , 2011. Vol. 294, no 4, 683-693 p.
Keyword [en]
fiber types; intrafusal fibers; jaw muscle; skeletal muscle
National Category
Dentistry
Research subject
Odontology
Identifiers
URN: urn:nbn:se:umu:diva-41345DOI: 10.1002/ar.21347PubMedID: 21370492OAI: oai:DiVA.org:umu-41345DiVA: diva2:405701
Available from: 2011-03-23 Created: 2011-03-23 Last updated: 2017-12-11Bibliographically approved
In thesis
1. Extra- and intrafusal muscle fibre type compositions of the human masseter at young age.: In perspective of growth and functional maturation of the jaw-face motor system.
Open this publication in new window or tab >>Extra- and intrafusal muscle fibre type compositions of the human masseter at young age.: In perspective of growth and functional maturation of the jaw-face motor system.
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Muscles control body posture and movement by extrafusal and intrafusal (muscle spindle) fibres. The purpose of this thesis was to provide insight into the muscular basis for human jaw function at young age. Extrafusal and intrafusal fibres in the young masseter, and for comparison young biceps, were examined for composition of fibre types and myosin heavy chain (MyHC) isoforms by means of morphological, enzyme-histochemical, biochemical and immuno-histochemical techniques. For evaluation of plasticity during life span the data for young muscles were compared with previous reported data for adult and elderly muscles.

The results showed significant differences in extrafusal fibre types and MyHC expression between young masseter and young biceps and between young masseter and masseter in adults and elderly. Compared with young biceps, young masseter was more intricate in composition of extrafusal MyHC expression. Muscle spindles were larger and more frequent in the masseter than in the biceps. Masseter and biceps muscle spindles showed fundamental similarities but also marked differences in MyHC expression.

The results suggest that the young masseter is specialized in fibre types already at young age and shows a unique fibre type growth pattern. Whereas masseter extrafusal fibres display marked plasticity in fibre types and MyHC isoforms during life span muscle spindles/intrafusal fibres are morphologically mature already at young age and precede extrafusal fibres in growth and maturation. Results showed similarities in intrafusal MyHC expression between young masseter and biceps, but also differences implying muscle specific proprioceptive control. Differences in fibre types and MyHC expression between young masseter and young biceps extrafusal fibres are proposed to reflect diverse evolutionary and developmental origins and accord with the masseter and biceps being separate allotypes of muscle.

Place, publisher, year, edition, pages
Umeå: Umeå University, 2011. 76 p.
Series
Umeå University odontological dissertations, ISSN 0345-7532 ; 120
Keyword
jaw, limb, human, muscle, morphology, fibre type, myosin heavy chain, muscle spindle
National Category
Dentistry
Research subject
Human Anatomy
Identifiers
urn:nbn:se:umu:diva-46667 (URN)978-91-7459-285-6 (ISBN)
Public defence
2011-09-30, Tandläkarhögskolan, byggnad 1D, 9 tr., sal B, Umeå universitet, Umeå, 09:00 (Swedish)
Opponent
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Available from: 2011-09-09 Created: 2011-09-09 Last updated: 2012-11-09Bibliographically approved

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