Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study
2011 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 129, no 8, 2032-2037 p.Article in journal (Refereed) Published
Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
Place, publisher, year, edition, pages
Geneve: International union against cancer , 2011. Vol. 129, no 8, 2032-2037 p.
tumor necrosis factor (TNF)-α, soluble TNF receptors, inflammation, endometrial cancer, prospective
Cancer and Oncology
Research subject Pathology
IdentifiersURN: urn:nbn:se:umu:diva-41629DOI: 10.1002/ijc.25840ISI: 000294224300025PubMedID: 21154749OAI: oai:DiVA.org:umu-41629DiVA: diva2:407386