Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
2011 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 208, no 1, 13-21 p.Article in journal (Refereed) Published
Natural killer (NK) cells are known to mount a rapid response to several virus infections. In experimental models of acute viral infection, this response has been characterized by prompt NK cell activation and expansion followed by rapid contraction. In contrast to experimental model systems, much less is known about NK cell responses to acute viral infections in humans. We demonstrate that NK cells can rapidly expand and persist at highly elevated levels for >60 d after human hantavirus infection. A large part of the expanding NK cells expressed the activating receptor NKG2C and were functional in terms of expressing a licensing inhibitory killer cell immunoglobulin-like receptor (KIR) and ability to respond to target cell stimulation. These results demonstrate that NK cells can expand and remain elevated in numbers for a prolonged period of time in humans after a virus infection. In time, this response extends far beyond what is considered normal for an innate immune response.
Place, publisher, year, edition, pages
Rockefeller University Press, 2011. Vol. 208, no 1, 13-21 p.
natural killer cells, human cytomegalovirus infection, immunodeficiency syndrome AIDS, Barr virus infection, target cells, T-cells, class-I, mediated cytotoxicity, hemorrhagic fever, adaptive immunity
IdentifiersURN: urn:nbn:se:umu:diva-41728DOI: 10.1084/jem.20100762ISI: 000286309300002PubMedID: 21173105OAI: oai:DiVA.org:umu-41728DiVA: diva2:407674