Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes.
2010 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 184, no 10, 5537-5544 p.Article in journal (Refereed) Published
Tuning of TCR-mediated activation was demonstrated to be critical for lineage fate in T cell development, as well as in the control of autoimmunity. In this study, we identify a novel diabetes susceptibility gene, Idd28, in the NOD mouse and provide evidence that Cd3zeta (Cd247) constitutes a prime candidate gene for this locus. Moreover, we show that the allele of the Cd3zeta gene expressed in NOD and DBA/2 mouse strains confers lower levels of T cell activation compared with the allele expressed by C57BL/6 (B6), BALB/c, and C3H/HeJ mice. These results support a model in which the development of autoimmune diabetes is dependent on a TCR signal mediated by a less-efficient NOD allele of the Cd3zeta gene.
Place, publisher, year, edition, pages
2010. Vol. 184, no 10, 5537-5544 p.
Immunology in the medical area
Research subject Medicine
IdentifiersURN: urn:nbn:se:umu:diva-41762DOI: 10.4049/jimmunol.0904012ISI: 000277530700014PubMedID: 20400699OAI: oai:DiVA.org:umu-41762DiVA: diva2:407740