Change search
ReferencesLink to record
Permanent link

Direct link
Type specificity and significance of different isotypes of serum antibodies to human papillomavirus capsids.
Show others and affiliations
2000 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, Vol. 181, no 2, 456-62 p.Article in journal (Refereed) Published
Abstract [en]

Isotype-specific serum antibody responses against human papillomavirus (HPV) type 16 were evaluated by use of cross-sectional, prospective, and population-based seroepidemiologic studies. IgG1 and IgA were the most abundant isotypes. No sample contained IgG2, and <25 samples contained IgG3 or IgM. Total IgG, IgA, and IgG1 were HPV type specific and were associated with HPV-16 DNA (odds ratios [ORs], 5.4, 5.0, and 5.9, respectively; P<.001) but not with other HPV DNA (ORs, 1.2, 1.2, and 0.8, respectively; P value was not significant). Total IgG and IgG1 were strongly associated with number of lifetime sex partners (P<.001); IgA was only associated with number of recent sex partners and lifetime sex partners among younger women. Total IgG, IgG1, and IgA were associated with cervical intraepithelial neoplasia type III and also predicted risk of future cervical neoplasia. IgG and IgG1 appeared to mark lifetime cumulative exposure, whereas IgA may mark recent or ongoing infection.

Place, publisher, year, edition, pages
2000. Vol. 181, no 2, 456-62 p.
URN: urn:nbn:se:umu:diva-41855DOI: 10.1086/315232PubMedID: 10669326OAI: diva2:407960
Available from: 2011-04-01 Created: 2011-04-01 Last updated: 2011-04-04

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wadell, G
By organisation
In the same journal
Journal of Infectious Diseases

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link