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Sialic acid tissue distribution and influenza virus tropism
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
2008 (English)In: Influenza and other respiratory viruses, ISSN 1750-2659, Vol. 2, no 5, 147-154 p.Article in journal (Refereed) Published
Abstract [en]

Avian influenza A viruses exhibit a strong preference for using alpha2,3-linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for alpha2,3-linked sialic acid.

Place, publisher, year, edition, pages
Wiley , 2008. Vol. 2, no 5, 147-154 p.
Keyword [en]
eye, influenza, receptor, sialic acid, tropism
Identifiers
URN: urn:nbn:se:umu:diva-41892DOI: 10.1111/j.1750-2659.2008.00051.xPubMedID: 19453419OAI: oai:DiVA.org:umu-41892DiVA: diva2:408002
Available from: 2011-04-01 Created: 2011-04-01 Last updated: 2011-06-17Bibliographically approved

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