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Secondary antibodies as tools to improve tumor to non tumor ratio at radioimmunolocalisation and radioimmunotherapy.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
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1996 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 35, no 3, 281-285 p.Article in journal (Refereed) Published
Abstract [en]

One way of selectively improving the efficiency of radioimmunolocalization and radioimmunotherapy is to eliminate redundant, circulating, non-targeting radiolabeled antibodies after saturation of the target sites. Secondary antibodies of different types have been proposed as clearing agents for such purposes. The conceptually different approaches of the 'secondary antibody' strategy including its advantages and limitations are discussed. This mini-review also presents a model describing the kinetics of the components (the antigen, the primary and secondary antibodies) and approaches required to improve the efficacy of both radioimmunolocalization and radioimmunotherapy.

Place, publisher, year, edition, pages
1996. Vol. 35, no 3, 281-285 p.
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URN: urn:nbn:se:umu:diva-41916PubMedID: 8679257OAI: oai:DiVA.org:umu-41916DiVA: diva2:408122
Available from: 2011-04-04 Created: 2011-04-04 Last updated: 2017-12-11

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Riklund, KatrineHietala, Sven-OlaStigbrand, Torgny
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