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Radioimmunodetection of ovarian cancer.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry.
1993 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 32, no 7-8, 729-734 p.Article in journal (Refereed) Published
Abstract [en]

Radioimmunoscintigraphy (RIS) is a potentially valuable method for the detection of primary, secondary and recurrent malignant tumours. Antigens that have been used for monitoring as well as for RIS of ovarian carcinomas include CA 125, PLAP, HMFG, and CA 19-9. Between 70 and 100% of the tumours have been detected at RIS when these antigens have been used. Conventional methods, e.g., computerized tomography (CT) and ultrasonography (US), demonstrate similar or lower detection rate than RIS for tumour diagnosis. RIS gives additional information to conventional radiological methods (CT and US) for the detection of occult ovarian carcinomas. A review of earlier investigations is given and our own recent results using PLAP as a target antigen are presented. The future potential of the technology is discussed.

Place, publisher, year, edition, pages
1993. Vol. 32, no 7-8, 729-734 p.
Identifiers
URN: urn:nbn:se:umu:diva-41921PubMedID: 8305219OAI: oai:DiVA.org:umu-41921DiVA: diva2:408129
Available from: 2011-04-04 Created: 2011-04-04 Last updated: 2017-12-11

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Riklund, KatrineHietala, Sven-OlaStigbrand, Torgny
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