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Endogenous matrix-derived inhibitors of angiogenesis
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
2010 (English)In: Pharmaceuticals, Vol. 3, 3021-3039 p.Article in journal (Refereed) Published
Abstract [en]

Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM) surrounding cells. Many matrix-derived inhibitors of angiogenesis, such as endostatin, tumstatin, canstatin and arresten, are bioactive fragments of larger ECM molecules. These substances become released upon proteolysis of the ECM and the vascular basement membrane (VBM) by enzymes of the tumor microenvironment. Although the role of matrix-derived angiogenesis inhibitors is well studied in animal models of cancer, their role in human cancers is less established. In this review we discuss the current knowledge about these molecules and their potential use as cancer therapeutics and biomarkers.

Place, publisher, year, edition, pages
2010. Vol. 3, 3021-3039 p.
Keyword [en]
angiogenesis; extracellular matrix; collagen; cancer; therapy; biomarker
URN: urn:nbn:se:umu:diva-41914DOI: 10.3390/ph3103021OAI: diva2:408144
Available from: 2011-04-04 Created: 2011-04-04 Last updated: 2011-04-05Bibliographically approved

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