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Ebola virus infection inversely correlates with the overall expression levels of promyelocytic leukaemia (PML) protein in cultured cells
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
2003 (English)In: BMC Microbiology, ISSN 1471-2180, Vol. 3, 6- p.Article in journal (Refereed) Published
Abstract [en]

We have established a simple fixation and immunofluorescence staining procedure that allows specific co-detection and precise sub-cellular localization of the PML nuclear bodies and the Ebola virus encoded proteins NP, VP35 and VP40 in formaldehyde treated cells. Interferon-alpha treatment delays virus production in vitro. Intact PML bodies may play an anti-viral role in Ebola infected cells.

Place, publisher, year, edition, pages
2003. Vol. 3, 6- p.
URN: urn:nbn:se:umu:diva-42050DOI: 10.1186/1471-2180-3-6PubMedID: 12697055OAI: diva2:408449
Available from: 2011-04-05 Created: 2011-04-05 Last updated: 2011-04-05Bibliographically approved

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Elgh, Fredrik
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