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Approaches for imaging islets
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Department of Nuclear Medicine, Nijmegen, Netherlands.
2010 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 654, 39-57 p.Article in journal (Refereed) Published
Abstract [en]

The establishment of improved technologies for imaging of the pancreas is a key element in addressing several aspects of diabetes pathogenesis. In this respect, the development of a protocol that allows for non-invasive scoring of human islets, or islet beta-cells, is of particular importance. The development of such a technology would have profound impact on both clinical and experimental medicine, ranging from early diagnosis of diabetes to the evaluation of therapeutic regimes. Another important task is the development of modalities for high-resolution imaging of experimental animal models for diabetes. Rodent models for diabetes research have for decades been instrumental to the diabetes research community. The ability to image, and to accurately quantify, key players of diabetogenic processes with molecular specificity will be of great importance for elucidating mechanistic aspects of the disease. This chapter aims to overview current progress within these research areas.

Place, publisher, year, edition, pages
Springer Netherlands, 2010. Vol. 654, 39-57 p.
Keyword [en]
Nuclear imaging, Optical imaging, Islets, β-cell mass
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-42130DOI: 10.1007/978-90-481-3271-3_3ISI: 000278074700003PubMedID: 20217493OAI: oai:DiVA.org:umu-42130DiVA: diva2:408698
Note

ISBN 978-90-481-3270-6 (Print), 978-90-481-3271-3 (Online)

Available from: 2011-04-06 Created: 2011-04-06 Last updated: 2017-12-11Bibliographically approved

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