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Neural differentiation and therapeutic potential of adipose tissue derived stem cells
University Hospitals of Basel and Lausanne.
University of Manchester.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
2010 (English)In: Current stem cell research & therapy, ISSN 1574-888X, Vol. 5, no 2, 153-160 p.Article, review/survey (Refereed) Published
Abstract [en]

Neural tissue has historically been regarded as having poor regenerative capacity but recent advances in the growing fields of tissue engineering and regenerative medicine have opened new hopes for the treatment of nerve injuries and neurodegenerative disorders. Adipose tissue has been shown to contain a large quantity of adult stem cells (ASC). These cells can be easily harvested with low associated morbidity and because of their potential to differentiate into multiple cell types, their use has been suggested for a wide variety of therapeutic applications. In this review we examine the evidence indicating that ASC can stimulate nerve regeneration by both undergoing neural differentiation and through the release of a range of growth factors. We also discuss some of the issues that need to be addressed before ASC can be developed as an effective cellular therapy for the treatment of neural tissue disorders.

Place, publisher, year, edition, pages
2010. Vol. 5, no 2, 153-160 p.
Keyword [en]
Nerve regeneration, adipose stem cells, nerve conduits, central nervous system, peripheral nervous system
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-42247DOI: 10.2174/157488810791268645ISI: 000208262700012PubMedID: 19941451OAI: oai:DiVA.org:umu-42247DiVA: diva2:409009
Available from: 2011-04-06 Created: 2011-04-06 Last updated: 2015-10-09Bibliographically approved

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Kingham, Paul J

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