VKORC1-1639G>A, CYP2C9, EPHX1691A>G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in southwest China
2010 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 66, no 12, 1217-1227 p.Article in journal (Refereed) Published
There were great interindividual differences in warfarin maintenance dosage (ranging from 0.6 to 8.4 mg/day) among the 127 patients with mechanical heart valve prostheses. VKORC1-1639G>A, CYP2C9, EPHX1691A>G polymorphism, body weight, and age were found to affect the dose demands. Multiple linear regression models incorporating genetic polymorphisms of VKORC1, CYP2C9, EPHX1691A>G, and the nongenetic factors of age and body weight were developed, and explained up to 76.8% of the total variation (adjusted R (2) of 0.743) in warfarin maintenance doses in southwest Chinese patients with mechanical heart valve prostheses.
Place, publisher, year, edition, pages
2010. Vol. 66, no 12, 1217-1227 p.
Gene polymorphism, Warfarin therapy, SNP, CYP2C9, VKORC1-1639G>A, EPHX1691A>G, Southwest Han Chinese patients, Mechanical heart valve prostheses
Other Clinical Medicine
Research subject Clinical Chemistry
IdentifiersURN: urn:nbn:se:umu:diva-42279DOI: 10.1007/s00228-010-0863-9PubMedID: 20842355OAI: oai:DiVA.org:umu-42279DiVA: diva2:409031