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VKORC1-1639G>A, CYP2C9, EPHX1691A>G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in southwest China
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry. Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Pharmacology.
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2010 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 66, no 12, 1217-1227 p.Article in journal (Refereed) Published
Abstract [en]

There were great interindividual differences in warfarin maintenance dosage (ranging from 0.6 to 8.4 mg/day) among the 127 patients with mechanical heart valve prostheses. VKORC1-1639G>A, CYP2C9, EPHX1691A>G polymorphism, body weight, and age were found to affect the dose demands. Multiple linear regression models incorporating genetic polymorphisms of VKORC1, CYP2C9, EPHX1691A>G, and the nongenetic factors of age and body weight were developed, and explained up to 76.8% of the total variation (adjusted R (2) of 0.743) in warfarin maintenance doses in southwest Chinese patients with mechanical heart valve prostheses.

Place, publisher, year, edition, pages
2010. Vol. 66, no 12, 1217-1227 p.
Keyword [en]
Gene polymorphism, Warfarin therapy, SNP, CYP2C9, VKORC1-1639G>A, EPHX1691A>G, Southwest Han Chinese patients, Mechanical heart valve prostheses
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Other Clinical Medicine
Research subject
Clinical Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-42279DOI: 10.1007/s00228-010-0863-9PubMedID: 20842355OAI: oai:DiVA.org:umu-42279DiVA: diva2:409031
Available from: 2011-04-06 Created: 2011-04-06 Last updated: 2017-12-11Bibliographically approved

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CiteExportLink to record
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