Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
2010 (English)In: Lancet Neurology, ISSN 1474-4422, E-ISSN 1474-4465, Vol. 9, no 10, 986-994 p.Article in journal (Refereed) Published
We have found strong evidence of a genetic association of two single nucleotide polymorphisms on chromosome 9 with sporadic ALS, in line with findings from previous independent GWAS of ALS and linkage studies of ALS-frontotemporal dementia. Our findings together with these earlier findings suggest that genetic variation at this locus on chromosome 9 causes sporadic ALS and familial ALS-frontotemporal dementia. Resequencing studies and then functional analysis should be done to identify the defective gene.
Place, publisher, year, edition, pages
2010. Vol. 9, no 10, 986-994 p.
IdentifiersURN: urn:nbn:se:umu:diva-42297DOI: 10.1016/S1474-4422(10)70197-6ISI: 000283616700013PubMedID: 20801717OAI: oai:DiVA.org:umu-42297DiVA: diva2:409090