β-cell function in obese-hyperglycemic mice [ob/ob Mice]
2010 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, Vol. 654, 463-477 p.Article in journal (Refereed) Published
This review summarizes key aspects of what has been learned about the physiology of pancreatic islets and leptin deficiency from studies in obese ob/ob mice. ob/ob Mice lack functional leptin. They are grossly overweight and hyperphagic particularly at young ages and develop severe insulin resistance with hyperglycemia and hyperinsulinemia. ob/ob Mice have large pancreatic islets. The beta-cells respond adequately to most stimuli, and ob/ob mice have been used as a rich source of pancreatic islets with high insulin release capacity. ob/ob Mice can perhaps be described as a model for the prediabetic state. The large capacity for islet growth and insulin release makes ob/ob mice a good model for studies on how beta-cells can cope with prolonged functional stress.
Place, publisher, year, edition, pages
Springer Netherlands, 2010. Vol. 654, 463-477 p.
ob/ob, Mice, Leptin, Growth
Cell and Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-42396DOI: 10.1007/978-90-481-3271-3_20ISI: 000278074700020PubMedID: 20217510OAI: oai:DiVA.org:umu-42396DiVA: diva2:409182
ISBN: 978-90-481-3270-6 (Print), 978-90-481-3271-3 (Online)2011-04-072011-04-072013-07-03Bibliographically approved