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β-cell function in obese-hyperglycemic mice [ob/ob Mice]
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
2010 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, Vol. 654, 463-477 p.Article in journal (Refereed) Published
Abstract [en]

This review summarizes key aspects of what has been learned about the physiology of pancreatic islets and leptin deficiency from studies in obese ob/ob mice. ob/ob Mice lack functional leptin. They are grossly overweight and hyperphagic particularly at young ages and develop severe insulin resistance with hyperglycemia and hyperinsulinemia. ob/ob Mice have large pancreatic islets. The beta-cells respond adequately to most stimuli, and ob/ob mice have been used as a rich source of pancreatic islets with high insulin release capacity. ob/ob Mice can perhaps be described as a model for the prediabetic state. The large capacity for islet growth and insulin release makes ob/ob mice a good model for studies on how beta-cells can cope with prolonged functional stress.

Place, publisher, year, edition, pages
Springer Netherlands, 2010. Vol. 654, 463-477 p.
Keyword [en]
ob/ob, Mice, Leptin, Growth
National Category
Cell and Molecular Biology
URN: urn:nbn:se:umu:diva-42396DOI: 10.1007/978-90-481-3271-3_20ISI: 000278074700020PubMedID: 20217510OAI: diva2:409182

ISBN: 978-90-481-3270-6 (Print), 978-90-481-3271-3 (Online)

Available from: 2011-04-07 Created: 2011-04-07 Last updated: 2013-07-03Bibliographically approved

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