Change search
ReferencesLink to record
Permanent link

Direct link
MRI-guided STN DBS in Parkinson's disease without microelectrode recording: efficacy and safety
Show others and affiliations
2011 (English)In: Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, E-ISSN 1468-330X, Vol. 82, no 4, 358-363 p.Article in journal (Refereed) Published
Abstract [en]

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a commonly employed therapeutic procedure for patients with Parkinson's disease uncontrolled by medical therapies. This series describes the outcomes of 79 consecutive patients that underwent bilateral STN DBS at the National Hospital for Neurology and Neurosurgery between November 2002 and November 2008 using an MRI-guided surgical technique without microelectrode recording. Patients underwent immediate postoperative stereotactic MR imaging. The mean (SD) error in electrode placement was 1.3 (0.6)&emsp14;mm. There were no haemorrhagic complications. At a median follow-up period of 12&emsp14;months, there was a mean improvement in the off-medication motor part of the Unified Parkinson's Disease Rating Scale (UPDRS III) of 27.7 points (SD 13.8) equivalent to a mean improvement of 52% (p<0.0001). In addition, there were significant improvements in dyskinesia duration, disability and pain, with a mean reduction in on-medication dyskinesia severity (sum of dyskinesia duration, disability and pain from UPDRS IV) from 3.15 (SD 2.33) pre-operatively, to 1.56 (SD 1.92) post-operatively (p=0.0001). Quality of life improved by a mean of 5.5 points (median 7.9 points, SD 17.3) on the Parkinson's disease Questionnaire 39 summary index. This series confirms that image-guided STN DBS without microelectrode recording can lead to substantial improvements in motor disability of well-selected PD patients with accompanying improvements in quality of life and most importantly, with very low morbidity.

Place, publisher, year, edition, pages
2011. Vol. 82, no 4, 358-363 p.
Keyword [en]
deep-brain-stimulation; subthalamic nucleus stimulation; magnetic-resonance; movement-disorders; risk-factors; hemorrhage; outcomes; implantation; metaanalysis; pallidotomy
National Category
URN: urn:nbn:se:umu:diva-42438DOI: 10.1136/jnnp.2010.205542PubMedID: 20571041OAI: diva2:409243
Available from: 2011-04-07 Created: 2011-04-07 Last updated: 2011-09-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hariz, Marwan
By organisation
In the same journal
Journal of Neurology, Neurosurgery and Psychiatry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 36 hits
ReferencesLink to record
Permanent link

Direct link