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Deep brain stimulation in the treatment of depression
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2011 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 123, no 1, 4-11 p.Article in journal (Refereed) Published
Abstract [en]

Objective:  To present the technique of deep brain stimulation (DBS) and to evaluate the studies conducted on DBS in the treatment of therapy-refractory major depressive disorder (MDD).

Method:  A review of the literature on DBS in the treatment of MDD was conducted.

Results:  The results of DBS in MDD have been presented in 2 case reports and 3 studies of 47 patients operated upon in 5 different target areas. Positive effects have been presented in all studies and side effects have been minor. DBS in the nucleus accumbens resulted in a mean reduction of Hamilton depression rating scale (HDRS) of 36% after 1 year and 30% of the 10 patients achieved remission. DBS in the internal capsule/ventral striatum resulted in a reduction of 44% after 1 year, and at the last evaluation after in mean 2 years, 40% of the 15 patients were in remission. The 20 patients with subcallosal cingulated gyrus DBS had a reduction of HDRS of 52% after 1 year, and 35% were within 1 point from remission or in remission.

Conclusion:  DBS is a promising treatment for therapy-refractory MDD. The published experience is, however, limited, and the method is at present an experimental therapy.

Place, publisher, year, edition, pages
2011. Vol. 123, no 1, 4-11 p.
Keyword [en]
deep brain stimulation; depression; stereotaxy
National Category
Neurology Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-42507DOI: 10.1111/j.1600-0447.2010.01625.xOAI: oai:DiVA.org:umu-42507DiVA: diva2:409436
Available from: 2011-04-08 Created: 2011-04-08 Last updated: 2017-12-11Bibliographically approved

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Blomstedt, PatricSjöberg, RichardHansson, MajaBodlund, OweHariz, Marwan I
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