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Ribosylurea accumulates in yeast urc4 mutants
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2010 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 29, no 4-6, p. 433-437Article in journal (Refereed) Published
Abstract [en]

Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following organic synthesis of ribosylurea. This finding demonstrates that in the URC pyrimidine degradation pathway, the opening of the uracil ring takes place when uracil is attached to the ribose moiety. Ribosylurea has not been reported in the cell metabolism before and the two observed compounds likely represent an equilibrium mixture of the pyranosyl and furanosyl forms.

Place, publisher, year, edition, pages
2010. Vol. 29, no 4-6, p. 433-437
Keywords [en]
Uracil degradation, ribosylurea, URC pathway, Saccharomyces (Lachancea) kluyveri
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-42558DOI: 10.1080/15257771003741265ISI: 000278713200029PubMedID: 20544532Scopus ID: 2-s2.0-77953701792OAI: oai:DiVA.org:umu-42558DiVA, id: diva2:409655
Available from: 2011-04-11 Created: 2011-04-11 Last updated: 2023-03-24Bibliographically approved

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Vodnala, MunenderDomkin, VladimirHofer, Anders

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