Extraocular muscles: extraocular muscle involvement in disease
2010 (English)In: Encyclopedia of the eye / [ed] Joseph C. Besharse, Darlene A. Dartt, Reza Dana, Amsterdam: Elsevier, 2010, , 6 p.99-104 p.Chapter in book (Other academic)
The extraocular muscles (EOMs) have unique functional and structural properties that truly set them apart from the other skeletal muscles in the body. Their most outstanding feature is a distinct behavior in disease. The EOMs remain unaffected in Duchenne muscular dystrophy and merosin-deficient congenital muscle dystrophy, two devastating muscle diseases causing severe handicap and precocious death. The EOMs are remarkably spared in motor neuron diseases such as amyotrophic lateral sclerosis, also a lethal neuromuscular disease. In contrast, these muscles are selectively affected in the Miller Fisher syndrome, and they are often the primary target in myasthenia gravis – two diseases affecting the neuromuscular junction.
Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2010. , 6 p.99-104 p.
, Encyclopedia of the eye, 2
Amyotrophic lateral sclerosis; Duchenne muscular dystrophy; Extraocular muscle; Merosin-deficient congenital muscle dystrophy; Miller Fisher syndrome; Mitochondrial myopathies; Myasthenia gravis; Ocular myasthenia
Research subject Ophtalmology
IdentifiersURN: urn:nbn:se:umu:diva-42561DOI: 10.1016/B978-0-12-374203-2.00279-7ISBN: 978-0-12-374203-2OAI: oai:DiVA.org:umu-42561DiVA: diva2:409717