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Extraocular muscles: extraocular muscle involvement in disease
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2010 (English)In: Encyclopedia of the eye / [ed] Joseph C. Besharse, Darlene A. Dartt, Reza Dana, Amsterdam: Elsevier, 2010, , 6 p.99-104 p.Chapter in book (Other academic)
Abstract [en]

The extraocular muscles (EOMs) have unique functional and structural properties that truly set them apart from the other skeletal muscles in the body. Their most outstanding feature is a distinct behavior in disease. The EOMs remain unaffected in Duchenne muscular dystrophy and merosin-deficient congenital muscle dystrophy, two devastating muscle diseases causing severe handicap and precocious death. The EOMs are remarkably spared in motor neuron diseases such as amyotrophic lateral sclerosis, also a lethal neuromuscular disease. In contrast, these muscles are selectively affected in the Miller Fisher syndrome, and they are often the primary target in myasthenia gravis – two diseases affecting the neuromuscular junction.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2010. , 6 p.99-104 p.
, Encyclopedia of the eye, 2
Keyword [en]
Amyotrophic lateral sclerosis; Duchenne muscular dystrophy; Extraocular muscle; Merosin-deficient congenital muscle dystrophy; Miller Fisher syndrome; Mitochondrial myopathies; Myasthenia gravis; Ocular myasthenia
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URN: urn:nbn:se:umu:diva-42561DOI: 10.1016/B978-0-12-374203-2.00279-7ISBN: 978-0-12-374203-2OAI: diva2:409717
Available from: 2011-04-11 Created: 2011-04-11 Last updated: 2014-04-10Bibliographically approved

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