A systems biology model of the regulatory network in Populus leaves reveals interacting regulators and conserved regulation
2011 (English)In: BMC Plant Biology, ISSN 1471-2229, Vol. 11, 13- p.Article in journal (Refereed) Published
We outline a computationally inferred model of the regulatory network of Populus leaves, and show how treating genes as interacting, rather than individual, entities identifies new regulators compared to traditional genomics analysis. Although systems biology models should be used with care considering the complexity of regulatory programs and the limitations of current genomics data, methods describing interactions can provide hypotheses about the underlying cause of emergent properties and are needed if we are to identify target genes other than those constituting the "low hanging fruit" of genomic analysis.
Place, publisher, year, edition, pages
2011. Vol. 11, 13- p.
gene-expression data; arabidopsis; sequence; database; trichocarpa; responses; elements; genomes; modules; tools
IdentifiersURN: urn:nbn:se:umu:diva-42682DOI: 10.1186/1471-2229-11-13PubMedID: 21232107OAI: oai:DiVA.org:umu-42682DiVA: diva2:409959