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Booster vaccination with recombinant hepatitis B vaccine four years after priming with one single dose
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases. (Clas Ahlm)
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
(tidigare Infektion UmU)
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1999 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 17, no 17, 2162-2165 p.Article in journal (Refereed) Published
Abstract [en]

We here studied the antibody response to a booster dose four years after the administration of one single dose of recombinant HB vaccine. Before receiving the booster dose, levels of protective antibodies (anti-HBs) were generally low and 24/41 (59%) individuals lacked detectable antibodies (< 1 IU/L). Within 14 d of booster vaccination, 36/38 (95%) vaccinees showed levels of antibodies > 100 IU/L. Notably, these levels were at least as high as those of a reference group 12 months after initiation of vaccination according to the standard three-dose vaccination at intervals of 0, 1 and 6 months. In conclusion, one single dose of HB vaccine seemed to confer on young healthy individuals a well preserved B cell memory, disclosed as a rapid and strong antibody response to a second dose four years later.

Place, publisher, year, edition, pages
1999. Vol. 17, no 17, 2162-2165 p.
Keyword [en]
Hepatitis B; Vaccination; Immunity
Identifiers
URN: urn:nbn:se:umu:diva-42767DOI: 10.1016/S0264-410X(99)00012-2PubMedID: 10367949OAI: oai:DiVA.org:umu-42767DiVA: diva2:410334
Available from: 2011-04-13 Created: 2011-04-13 Last updated: 2017-12-11Bibliographically approved

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Wiström, JohanAhlm, ClasTärnvik, Arne

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