Booster vaccination with recombinant hepatitis B vaccine four years after priming with one single dose
1999 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 17, no 17, 2162-2165 p.Article in journal (Refereed) Published
We here studied the antibody response to a booster dose four years after the administration of one single dose of recombinant HB vaccine. Before receiving the booster dose, levels of protective antibodies (anti-HBs) were generally low and 24/41 (59%) individuals lacked detectable antibodies (< 1 IU/L). Within 14 d of booster vaccination, 36/38 (95%) vaccinees showed levels of antibodies > 100 IU/L. Notably, these levels were at least as high as those of a reference group 12 months after initiation of vaccination according to the standard three-dose vaccination at intervals of 0, 1 and 6 months. In conclusion, one single dose of HB vaccine seemed to confer on young healthy individuals a well preserved B cell memory, disclosed as a rapid and strong antibody response to a second dose four years later.
Place, publisher, year, edition, pages
1999. Vol. 17, no 17, 2162-2165 p.
Hepatitis B; Vaccination; Immunity
IdentifiersURN: urn:nbn:se:umu:diva-42767DOI: 10.1016/S0264-410X(99)00012-2PubMedID: 10367949OAI: oai:DiVA.org:umu-42767DiVA: diva2:410334