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The role of placental exosomes in reproduction
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Immunology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Immunology.
2010 (English)In: American Journal of Reproductive Immunology, ISSN 8755-8920, Vol. 63, no 6, 520-533 p.Article in journal (Refereed) Published
Abstract [en]

Cell communication comprises cell-cell contact, soluble mediators and intercellular nanotubes. There is, however, another cell-cell communication by released membrane-bound microvesicles that convey cell-cell contact 'by proxy' transporting signals/packages of information from donor to recipient cells locally and/or at a distance. The nanosized exosomes comprise a specialized type of microvesicles generated within multivesicular bodies (MVB) and released upon MVB fusion with the plasma membrane. Exosomes are produced by a variety of immune, epithelial and tumor cells. Upon contact, exosomes transfer molecules that can render new properties and/or reprogram their recipient cells. Recently, it was discovered that the syncytiotrophoblast constitutively and throughout the pregnancy secretes exosomes. The placenta-derived exosomes are immunosuppressive and carry proteins and RNA molecules that in a redundant way influence a number of mechanisms and promote the fetal allograft survival. In this review, we summarize the current knowledge on the nature of placenta-derived exosomes and discuss their role in pregnancy.

Place, publisher, year, edition, pages
2010. Vol. 63, no 6, 520-533 p.
Keyword [en]
Exosomes; FasL; MICA/B; microvesicles; placenta; ULBP
URN: urn:nbn:se:umu:diva-42831DOI: 10.1111/j.1600-0897.2010.00822.xISI: 000277521800011PubMedID: 20331583OAI: diva2:410496
Available from: 2011-04-13 Created: 2011-04-13 Last updated: 2011-05-16Bibliographically approved

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Mincheva-Nilsson, LuciaBaranov, Vladimir
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