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Mechanisms maintaining the dormancy and survival of mammalian primordial follicles
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
2010 (English)In: Trends in endocrinology and metabolism, ISSN 1043-2760, E-ISSN 1879-3061, Vol. 21, no 2, 96-103 p.Article in journal (Refereed) Published
Abstract [en]

To preserve the length of a woman's reproductive life it is essential that the majority of her ovarian primordial follicles are maintained in a quiescent state to provide a reserve for continuous reproductive success. The mechanisms maintaining the dormancy and survival of primordial follicles have been a mystery for decades. In recent years information provided by genetically modified mouse models has revealed a number of molecules whose functions are indispensable for the maintenance of follicular quiescence (including PTEN, Tsc1, Tsc2, Foxo3a, p27) and survival (PI3K signaling). Here we summarize this updated information, which hopefully will lead to a better understanding of the pathophysiology of the human ovary and provide potential therapeutic options for some types of infertility.

Place, publisher, year, edition, pages
2010. Vol. 21, no 2, 96-103 p.
Identifiers
URN: urn:nbn:se:umu:diva-42924DOI: 10.1016/j.tem.2009.10.001ISI: 000275156800006PubMedID: 19913438OAI: oai:DiVA.org:umu-42924DiVA: diva2:410771
Available from: 2011-04-14 Created: 2011-04-14 Last updated: 2011-05-04Bibliographically approved

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Zheng, WenjingLiu, Kui

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