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Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging.
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1998 (English)In: Science, ISSN 0036-8075, Vol. 279, no 5349, 373-7 p.Article in journal (Refereed) Published
Abstract [en]

The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.

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1998. Vol. 279, no 5349, 373-7 p.
URN: urn:nbn:se:umu:diva-42931PubMedID: 9430586OAI: diva2:410776
Available from: 2011-04-14 Created: 2011-04-14 Last updated: 2011-04-14

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Arnqvist, AnnaBorén, Thomas
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