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Fibronectin binding mediated by a novel class of surface organelles on Escherichia coli
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
1989 (English)In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 338, no 6217, 652-5 p.Article in journal (Refereed) Published
Abstract [en]

Gram-negative bacteria are known to produce two types of surface organelles: flagella, which are required for motility and chemotaxis, and pili (fimbriae), which play a part in the interaction of bacteria with other bacteria and with eukaryotic host cells. Here we report a third class of E. coli surface organelles for which we propose the name curli. Curli are coiled surface structures composed of a single type of subunit, the curlin, which differs from all known pilin proteins and is synthesized in the absence of a cleavable signal peptide. Although the gene encoding this structural subunit, crl, is present and transcribed in most natural isolates of E. coli, only certain strains are able to assemble the subunit protein into curli. This assembly process occurs preferentially at growth temperatures below 37 degrees C. The ability of curli to mediate binding to fibronectin may be a virulence-associated property for wound colonization and for the colonization of fibronectin-coated surfaces.

Place, publisher, year, edition, pages
1989. Vol. 338, no 6217, 652-5 p.
Identifiers
URN: urn:nbn:se:umu:diva-42937DOI: 10.1038/338652a0PubMedID: 2649795OAI: oai:DiVA.org:umu-42937DiVA: diva2:410782
Available from: 2011-04-14 Created: 2011-04-14 Last updated: 2017-12-11Bibliographically approved

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