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The solution NMR structure of a blue-green algae hepatotoxin, microcystin-RR--a comparison with the structure of microcystin-LR.
1998 (English)In: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 258, no 2, 301-12 p.Article in journal (Refereed) Published
Abstract [en]

The microcystin-RR structures are compared with the structures of microcystin-LR in solution as well as in the crystal structure of the complex with protein phosphatase. The gross structures of the two peptides are similar, but with a more accentuated and compact saddle structure for microcystin-RR. The structural differences affect the hydrogen-bond pattern in the peptides and the location of the side chain of N-methyldehydroalanine, both of which are important for the ability of the peptide to form a tight complex with protein phosphatase. These structural differences may contribute to the observed differences in toxicity of microcystin-RR and microcystin-LR.

Place, publisher, year, edition, pages
1998. Vol. 258, no 2, 301-12 p.
Identifiers
URN: urn:nbn:se:umu:diva-42943PubMedID: 9874194OAI: oai:DiVA.org:umu-42943DiVA: diva2:410786
Available from: 2011-04-14 Created: 2011-04-14 Last updated: 2017-12-11

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