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Buffering and the evolution of chromosome-wide gene regulation
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Computational Life Science Cluster (CLiC))
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
2011 (English)In: Chromosoma, ISSN 0009-5915, E-ISSN 1432-0886, Vol. 120, no 3, 213-225 p.Article in journal (Refereed) Published
Abstract [en]

Copy number variation (CNV) in terms of aneuploidies of both entire chromosomes and chromosomal segments is an important evolutionary driving force, but it is inevitably accompanied by potentially problematic variations in gene doses and genomic instability. Thus, a delicate balance must be maintained between mechanisms that compensate for variations in gene doses (and thus allow such genomic variability) and selection against destabilizing CNVs. In Drosophila, three known compensatory mechanisms have evolved: a general segmental aneuploidy-buffering system and two chromosome-specific systems. The two chromosome-specific systems are the male-specific lethal complex, which is important for dosage compensation of the male X chromosome, and Painting of fourth, which stimulates expression of the fourth chromosome. In this review, we discuss the origin and function of buffering and compensation using Drosophila as a model.

Place, publisher, year, edition, pages
2011. Vol. 120, no 3, 213-225 p.
Keyword [en]
position-effect variegation; drosophila dosage compensation; nuclear-pore components; x-chromosome; histone h3; msl complex; 4th chromosome; dot chromosome; heterochromatin protein-1; melanogaster males
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-43226DOI: 10.1007/s00412-011-0319-8OAI: oai:DiVA.org:umu-43226DiVA: diva2:412389
Available from: 2011-04-22 Created: 2011-04-22 Last updated: 2017-12-11

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Publisher's full texthttp://www.ncbi.nlm.nih.gov/pubmed/21505791

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