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The spatial and temporal organization of ubiquitin networks
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Grabbe)
2011 (English)In: Nature reviews. Molecular cell biology, ISSN 1471-0072, Vol. 12, no 5, 295-307 p.Article in journal (Refereed) Published
Abstract [en]

In the past decade, the diversity of signals generated by the ubiquitin system has emerged as a dominant regulator of biological processes and propagation of information in the eukaryotic cell. A wealth of information has been gained about the crucial role of spatial and temporal regulation of ubiquitin species of different lengths and linkages in the nuclear factor-κB (NF-κB) pathway, endocytic trafficking, protein degradation and DNA repair. This spatiotemporal regulation is achieved through sophisticated mechanisms of compartmentalization and sequential series of ubiquitylation events and signal decoding, which control diverse biological processes not only in the cell but also during the development of tissues and entire organisms.

Place, publisher, year, edition, pages
2011. Vol. 12, no 5, 295-307 p.
URN: urn:nbn:se:umu:diva-43230DOI: 10.1038/nrm3099PubMedID: 21448225OAI: diva2:412396
Available from: 2011-04-22 Created: 2011-04-22 Last updated: 2011-05-11Bibliographically approved

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