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Signal sensory systems that impact σ(54)-dependent transcription
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Shingler, V.)
2011 (English)In: FEMS Microbiology Reviews, ISSN 0168-6445, E-ISSN 1574-6976, Vol. 35, no 3, 425-440 p.Article in journal (Refereed) Published
Abstract [en]

Alternative σ-factors of bacteria bind core RNA polymerase to program the specific promoter selectivity of the holoenzyme. Signal-responsive changes in the availability of different σ-factors redistribute the RNA polymerase among the distinct promoter classes in the genome for appropriate adaptive, developmental and survival responses. The σ(54) -factor is structurally and functionally distinct from all other σ-factors. Consequently, binding of σ(54) to RNA polymerase confers unique features on the cognate holoenzyme, which requires activation by an unusual class of mechano-transcriptional activators, whose activities are highly regulated in response to environmental cues. This review summarizes the current understanding of the mechanisms of transcriptional activation by σ(54) -RNA polymerase and highlights the impact of global regulatory factors on transcriptional efficiency from σ(54) -dependent promoters. These global factors include the DNA-bending proteins IHF and CRP, the nucleotide alarmone ppGpp, and the RNA polymerase-targeting protein DksA.

Place, publisher, year, edition, pages
2011. Vol. 35, no 3, 425-440 p.
Keyword [en]
bacterial transcription; AAA+ family; bacterial enhancer-binding proteins; IHF; ppGpp; DksA
URN: urn:nbn:se:umu:diva-43233DOI: 10.1111/j.1574-6976.2010.00255.xPubMedID: 21054445OAI: diva2:412403
Available from: 2011-04-22 Created: 2011-04-22 Last updated: 2012-09-04Bibliographically approved

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