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Dietary Immunomodulatory Factors in the Development of Immune Tolerance.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
2011 (English)In: Current Allergy and Asthma Reports, ISSN 1529-7322, Vol. 11, no 4, 325-333 p.Article in journal (Refereed) Published
Abstract [en]

Emerging evidence suggests that exposures during pregnancy and the early postnatal period can modify gene expression and disease propensity. Diet is a major environmental exposure, and dietary factors, including polyunsaturated fatty acids, probiotics, oligosaccharides, antioxidants, folate, and other vitamins, have effects on immune function. Some also have been implicated in reduced risk of allergy in observational studies. Intervention trials with polyunsaturated fatty acids, probiotics, and oligosaccharides suggest preliminary but as-of-yet-unconfirmed benefits. Food allergen avoidance during pregnancy, lactation, or infancy has provided no consistent evidence in allergy prevention and is no longer recommended. Rather, there is now a focus on food allergens in tolerance induction. Specific nutrients can induce changes in gene expression during early development and have been implicated in potentially heritable "epigenetic" changes in disease predisposition. Collectively, these observations emphasize that early exposures may modify tolerance development and that further research on these exposures should remain a priority.

Place, publisher, year, edition, pages
Springer , 2011. Vol. 11, no 4, 325-333 p.
Keyword [en]
Allergy prevention, Immune tolerance, Dietary immunomodulatory factors, Antioxidants, Complementary feeding, Folate, Vitamin D, Polyunsaturated fatty acids, Prebiotics, Probiotics
National Category
Respiratory Medicine and Allergy
URN: urn:nbn:se:umu:diva-43597DOI: 10.1007/s11882-011-0200-0PubMedID: 21538229OAI: diva2:414754
Available from: 2011-05-04 Created: 2011-05-04 Last updated: 2011-09-27Bibliographically approved

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