Change search
ReferencesLink to record
Permanent link

Direct link
Dual association of a TRKA polymorphism with schizophrenia.
Show others and affiliations
2011 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 21, no 3, 125-131 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.

METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.

RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.

CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins , 2011. Vol. 21, no 3, 125-131 p.
Keyword [en]
case-control study, meta-analysis, neurotrophic tyrosine kinase receptor 1, protective factor, risk factor
National Category
URN: urn:nbn:se:umu:diva-43908DOI: 10.1097/YPG.0b013e3283437194PubMedID: 21317683OAI: diva2:417270
Available from: 2011-05-16 Created: 2011-05-16 Last updated: 2015-12-14

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Norrback, Karl-FredrikAdolfsson, Rolf
By organisation
In the same journal
Psychiatric Genetics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 57 hits
ReferencesLink to record
Permanent link

Direct link