Dual association of a TRKA polymorphism with schizophrenia.
2011 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 21, no 3, 125-131 p.Article in journal (Refereed) Published
OBJECTIVE: An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.
METHODS: We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.
RESULT: Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.
CONCLUSION: An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins , 2011. Vol. 21, no 3, 125-131 p.
case-control study, meta-analysis, neurotrophic tyrosine kinase receptor 1, protective factor, risk factor
IdentifiersURN: urn:nbn:se:umu:diva-43908DOI: 10.1097/YPG.0b013e3283437194PubMedID: 21317683OAI: oai:DiVA.org:umu-43908DiVA: diva2:417270