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[3H]WIN 35,428 binding in the human brain.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
1996 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 706, no 2, 347-50 p.Article in journal (Refereed) Published
Abstract [en]

The binding of [3H]WIN 35,428 was studied in post-mortem human brain, including extrastriatal regions. In the putamen, dopamine almost completely inhibited the [3H]WIN 35,428 binding. Paroxetine inhibited the binding with similar affinity as cocaine, in the range 200-300 nM. In the frontal cortex, [3H]WIN 35,428 labelled cocaine- and alaproclate sensitive binding sites, of which a major fraction was of protein nature. The elucidation of the cocaine sensitive sites in the frontal cortex should be the subject of further research.

Place, publisher, year, edition, pages
1996. Vol. 706, no 2, 347-50 p.
URN: urn:nbn:se:umu:diva-43975PubMedID: 8822381OAI: diva2:417455
Available from: 2011-05-17 Created: 2011-05-17 Last updated: 2011-05-17

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