Change search
ReferencesLink to record
Permanent link

Direct link
Detection of expanded CAG repeats in bipolar affective disorder using the repeat expansion detection (RED) method.
Show others and affiliations
1995 (English)In: Neurobiology of Disease, ISSN 0969-9961, E-ISSN 1095-953X, Vol. 2, no 1, 55-62 p.Article in journal (Refereed) Published
Abstract [en]

Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II). The exact mode of inheritance of BPAD is unknown, but the recent demonstration of anticipation suggests that dynamic mutations could be involved in the clinical expression of the disease. We have used the repeat expansion detection (RED) method to test whether the anticipation in BPAD could be explained by the presence of expanded trinucleotide repeat sequences. Using a (CTG)10 oligonucleotide a significantly higher number of expanded CAG repeats were found in the genomic DNA of two independent samples of unrelated BPAD patients of Swedish and Belgian ancestry as compared with normal controls. The difference in repeat number was more consistent if data of the two samples of patients was pooled. In this study a CAG trinucleotide repeat expansion was associated for the first time with a major psychiatric disorder. It is possible that the CAG trinucleotide repeat expansion is involved in the clinical expression of BPAD and that it is the molecular basis explaining the phenomenon of anticipation observed in this disorder.

Place, publisher, year, edition, pages
1995. Vol. 2, no 1, 55-62 p.
URN: urn:nbn:se:umu:diva-43993PubMedID: 8980009OAI: diva2:417574
Available from: 2011-05-17 Created: 2011-05-17 Last updated: 2015-11-13

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Chotai, Jayanti
By organisation
In the same journal
Neurobiology of Disease

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link