Change search
ReferencesLink to record
Permanent link

Direct link
Anamnestic Immune Response in 3- to 4-year-old Children Previously Immunized With 10-valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine as 2 Dose or 3 Dose Priming and a Booster Dose in the First Year of Life.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Show others and affiliations
2011 (English)In: The Pediatric Infectious Disease Journal, ISSN 0891-3668, E-ISSN 1532-0987, Vol. 30, no 9, e155-e163 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:: Immunogenicity of 10-valent pneumococcal nontypeable Haemophilus influenzae proteind conjugate vaccine (PHiD-CV), administered as 2 dose or 3 dose priming followed by a booster dose, has been described previously. The present study evaluated immunologic memory following PHiD-CV vaccination according to these vaccination schedules. METHODS:: A dose of PHiD-CV (to test anamnestic responses) was administered to 172 children at 36 to 46 months of age; 110 of them had previously been vaccinated with PHiD-CV according to 2 + 1 or 3 + 1 schedules (PHiD-CV [2 + 1] and PHiD-CV [3 + 1] groups) and 62 were unprimed age-matched controls. To measure immune responses before and 7 to 10 days after the PHiD-CV dose, 22F-inhibition enzyme-linked immunosorbent assay and opsonophagocytic activity (OPA) assay were used. RESULTS:: Serotype-specific IgG geometric mean concentrations (GMCs) and OPA geometric mean titers (GMTs) increased substantially (from before to 7 to 10 days after the additional PHiD-CV dose) for all 10 vaccines and 2 cross-reactive serotypes (6A and 19A) in the children previously vaccinated with PHiD-CV, regardless of the vaccination schedule used. Antibody GMCs and OPA GMTs after the administration of the PHiD-CV dose were markedly higher in both previously PHiD-CV-vaccinated groups than in the unprimed control group, clearly demonstrating prior induction of immunologic memory. Antiprotein D antibody GMCs had also increased substantially from before to 7 to 10 days after vaccination in all 3 groups, with higher antibody GMCs in the previously vaccinated groups than in the control group. CONCLUSION:: PHiD-CV vaccination according to 2 + 1 or 3 + 1 schedules resulted in comparable anamnestic immune responses. These findings suggest that similar protective efficacy may be achieved with both the schedules.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins , 2011. Vol. 30, no 9, e155-e163 p.
National Category
URN: urn:nbn:se:umu:diva-45124DOI: 10.1097/INF.0b013e31821feeb7PubMedID: 21572373OAI: diva2:426099
Available from: 2011-06-22 Created: 2011-06-22 Last updated: 2011-09-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Silfverdal, Sven Arne
By organisation
In the same journal
The Pediatric Infectious Disease Journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 26 hits
ReferencesLink to record
Permanent link

Direct link