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Anamnestic Immune Response in 3- to 4-year-old Children Previously Immunized With 10-valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine as 2 Dose or 3 Dose Priming and a Booster Dose in the First Year of Life.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2011 (English)In: The Pediatric Infectious Disease Journal, ISSN 0891-3668, E-ISSN 1532-0987, Vol. 30, no 9, e155-e163 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:: Immunogenicity of 10-valent pneumococcal nontypeable Haemophilus influenzae proteind conjugate vaccine (PHiD-CV), administered as 2 dose or 3 dose priming followed by a booster dose, has been described previously. The present study evaluated immunologic memory following PHiD-CV vaccination according to these vaccination schedules. METHODS:: A dose of PHiD-CV (to test anamnestic responses) was administered to 172 children at 36 to 46 months of age; 110 of them had previously been vaccinated with PHiD-CV according to 2 + 1 or 3 + 1 schedules (PHiD-CV [2 + 1] and PHiD-CV [3 + 1] groups) and 62 were unprimed age-matched controls. To measure immune responses before and 7 to 10 days after the PHiD-CV dose, 22F-inhibition enzyme-linked immunosorbent assay and opsonophagocytic activity (OPA) assay were used. RESULTS:: Serotype-specific IgG geometric mean concentrations (GMCs) and OPA geometric mean titers (GMTs) increased substantially (from before to 7 to 10 days after the additional PHiD-CV dose) for all 10 vaccines and 2 cross-reactive serotypes (6A and 19A) in the children previously vaccinated with PHiD-CV, regardless of the vaccination schedule used. Antibody GMCs and OPA GMTs after the administration of the PHiD-CV dose were markedly higher in both previously PHiD-CV-vaccinated groups than in the unprimed control group, clearly demonstrating prior induction of immunologic memory. Antiprotein D antibody GMCs had also increased substantially from before to 7 to 10 days after vaccination in all 3 groups, with higher antibody GMCs in the previously vaccinated groups than in the control group. CONCLUSION:: PHiD-CV vaccination according to 2 + 1 or 3 + 1 schedules resulted in comparable anamnestic immune responses. These findings suggest that similar protective efficacy may be achieved with both the schedules.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins , 2011. Vol. 30, no 9, e155-e163 p.
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Pediatrics
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URN: urn:nbn:se:umu:diva-45124DOI: 10.1097/INF.0b013e31821feeb7PubMedID: 21572373OAI: oai:DiVA.org:umu-45124DiVA: diva2:426099
Available from: 2011-06-22 Created: 2011-06-22 Last updated: 2017-12-11Bibliographically approved

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Silfverdal, Sven Arne

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