Change search
ReferencesLink to record
Permanent link

Direct link
Wegener granulomatosis in children and young adults. A case study of ten patients.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Show others and affiliations
2000 (English)In: Pediatric nephrology (Berlin, West), ISSN 0931-041X, E-ISSN 1432-198X, Vol. 14, no 3, 208-13 p.Article in journal (Refereed) Published
Abstract [en]

This retrospective study reports seven children and three young adults (aged 11-30 years) who suffered from Wegener granulomatosis. Nine represent consecutive patients admitted to the Division of Nephrology over a period of 23 years. All patients had respiratory tract symptoms and renal involvement on admission. In several patients infiltrates on chest X-ray developed within 2 weeks of onset of symptoms. All patients survived. The median observation period was 9 years (range 13 months to 23 years). One patient progressed to end-stage renal disease. Nine patients initially received cyclophosphamide and steroids. After a median period of 9 months (range 6-31 months) the cyclophosphamide was replaced by azathioprine. Relapses occurred after a median of 28 months (range 4-120 months) in 80% of patients, in six of the eight patients causing a definite decrease in kidney function. We believe that early diagnosis and initiation of therapy reduce the extent of organ damage. Since relapses are frequent, these patients should be evaluated frequently.

Place, publisher, year, edition, pages
2000. Vol. 14, no 3, 208-13 p.
URN: urn:nbn:se:umu:diva-45343PubMedID: 10752759OAI: diva2:429256
Available from: 2011-07-04 Created: 2011-07-04 Last updated: 2011-07-04

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Gothefors, Leif
By organisation
In the same journal
Pediatric nephrology (Berlin, West)

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link