The prepuce: a mistake of nature?
1989 (English)In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 333, no 8638, 598-599 p.Article in journal (Refereed) Published
Retrospective studies suggest that circumcision of newborn boys will reduce the frequency of male early infantile urinary tract infection (UTI) by about 90%. If they are correct, this will be the first known instance of a common potentially lethal disease being preventable by extirpation of a piece of normal tissue. To reconcile the phenomenon with existing views of evolution and biology, it is suggested that the effects of one unphysiological intervention are counterbalancing those of another--ie, colonisation of the baby's gastrointestinal tract and genitals in maternity units by Escherichia coli strains of non-maternal origin, to which the baby has no passive immunity. As an alternative to circumcision to prevent early infantile male UTI, more natural colonisation could be promoted by strict rooming-in of mother and baby or by active colonisation of the baby with his mother's anaerobic gut flora.
Place, publisher, year, edition, pages
Elsevier Ltd. , 1989. Vol. 333, no 8638, 598-599 p.
Research subject Pediatrics
IdentifiersURN: urn:nbn:se:umu:diva-45383DOI: 10.1016/S0140-6736(89)91619-XPubMedID: 2564120OAI: oai:DiVA.org:umu-45383DiVA: diva2:429347
Originally published as Volume 1, Issue 8638, 1989.
Available online 22 September 2003.2011-07-042011-07-042011-09-22Bibliographically approved