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The prepuce: a mistake of nature?
Department of Paediatrics, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Department of Paediatrics, Sachs's Children's Hospital, Karolinska Institutet, Stockholm, Sweden.
Department of Paediatrics, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden.
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1989 (English)In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 333, no 8638, 598-599 p.Article in journal (Refereed) Published
Abstract [en]

Retrospective studies suggest that circumcision of newborn boys will reduce the frequency of male early infantile urinary tract infection (UTI) by about 90%. If they are correct, this will be the first known instance of a common potentially lethal disease being preventable by extirpation of a piece of normal tissue. To reconcile the phenomenon with existing views of evolution and biology, it is suggested that the effects of one unphysiological intervention are counterbalancing those of another--ie, colonisation of the baby's gastrointestinal tract and genitals in maternity units by Escherichia coli strains of non-maternal origin, to which the baby has no passive immunity. As an alternative to circumcision to prevent early infantile male UTI, more natural colonisation could be promoted by strict rooming-in of mother and baby or by active colonisation of the baby with his mother's anaerobic gut flora.

Place, publisher, year, edition, pages
Elsevier Ltd. , 1989. Vol. 333, no 8638, 598-599 p.
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-45383DOI: 10.1016/S0140-6736(89)91619-XPubMedID: 2564120OAI: oai:DiVA.org:umu-45383DiVA: diva2:429347
Note
Originally published as Volume 1, Issue 8638, 1989. Available online 22 September 2003.Available from: 2011-07-04 Created: 2011-07-04 Last updated: 2017-12-11Bibliographically approved

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Gothefors, Leif

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