Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds
2011 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 286, no 34, 29922-29931 p.Article in journal (Refereed) Published
A class of anti-virulence compounds, the salicylidene acylhydrazides, have been widely reported to block the function of the type three secretion system of several Gram-negative pathogens by a previously unknown mechanism. In this work, we provide the first identification of bacterial proteins that are targeted by this group of compounds. We provide evidence that their mode of action is likely to result from a synergistic effect arising from a perturbation of the function of several conserved proteins. We also examine the contribution of selected target proteins to the pathogenicity of Yersina pseudotuberculosis and to expression of virulence genes in Escherichia coli O157.
Place, publisher, year, edition, pages
American Society for Biochemistry and Molecular Biology , 2011. Vol. 286, no 34, 29922-29931 p.
Bacteria, Bacterial genetics, Gene regulation, Protein drug interactions, Protein secretion, Protein targeting, Transcription
IdentifiersURN: urn:nbn:se:umu:diva-45478DOI: 10.1074/jbc.M111.233858PubMedID: 21724850OAI: oai:DiVA.org:umu-45478DiVA: diva2:429696