Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study
2010 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 21, no 10, 1533-1544 p.Article in journal (Refereed) Published
Background Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer.
Methods Subjects were from the Västerbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15 years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression.
Results No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee ≥4 versus <1 occasions/day was associated with a reduced risk (HR = 0.52, CI = 0.30–0.88, p trend = 0.247). An increased risk of premenopausal and a reduced risk of postmenopausal breast cancer were found for both total (HRpremenopausal = 1.69, CI = 0.96–2.98, p trend = 0.015, HRpostmenopausal = 0.60, CI = 0.39–0.93, p trend = 0.006) and filtered coffee (HRpremenopausal = 1.76, CI = 1.04–3.00, p trend = 0.045, HRpostmenopausal = 0.52, CI = 0.30–0.88, p trend = 0.045). Boiled coffee was positively associated with the risk of respiratory tract cancer (HR = 1.81, CI = 1.06–3.08, p trend = 0.084), a finding limited to men. Main results for less common cancer types included total coffee in renal cell cancer (HR = 0.30, CI = 0.11–0.79, p trend = 0.009) and boiled coffee in pancreas cancer (HR = 2.51 CI = 1.15–5.50, p trend = 0.006).
Conclusion These findings demonstrate, for the first time, the potential relevance of brewing method in investigations of coffee consumption and cancer risk, but they must be confirmed in future studies.
Place, publisher, year, edition, pages
Springer Netherlands, 2010. Vol. 21, no 10, 1533-1544 p.
Cancer, Coffee, Caffeine, Risk factors, Brewing method
Cancer and Oncology Nutrition and Dietetics
Research subject Oncology
IdentifiersURN: urn:nbn:se:umu:diva-45497DOI: 10.1007/s10552-010-9582-xISI: 000281934800001PubMedID: 20512657OAI: oai:DiVA.org:umu-45497DiVA: diva2:429843
FunderSwedish Research CouncilForte, Swedish Research Council for Health, Working Life and Welfare