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Toxin-gene profile heterogeneity among endemic invasive European group A streptococcal isolates.
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2003 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 188, no 10, 1578-1586 p.Article in journal (Refereed) Published
Abstract [en]

We determined the toxin-gene profiles of 239 endemic, invasive group A streptococcal (GAS) isolates that circulated, within a 5-year period, in European university hospitals. Profiling was performed by use of multiplex polymerase chain reaction that screened for 9 streptococcal pyrogenic exotoxins (speA, speB, speC, speF, speG, speH, speJ, ssa, and smeZ). Analysis revealed that invasive GAS isolates do not share a common toxin-gene profile. Although all emm types were characterized by several different toxin-gene profiles, a predominance of 1 or 2 toxin-gene profiles could be observed, reflecting that a few invasive clones have spread successfully throughout the world. Remarkably, statistical pair-wise analysis of individual toxin genes revealed that strains that did not share the predominant profile still showed a nonrandom distribution of key toxin genes characteristic of the specific emm type. This could indicate that M proteins function, directly or indirectly, as barriers for horizontal gene exchange.

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2003. Vol. 188, no 10, 1578-1586 p.
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URN: urn:nbn:se:umu:diva-45521DOI: 10.1086/379230PubMedID: 14624385OAI: oai:DiVA.org:umu-45521DiVA: diva2:430087
Available from: 2011-07-07 Created: 2011-07-07 Last updated: 2017-12-11

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Charpentier, Emmanuelle

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