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Serum metabolite signature predicts the acute onset of diabetes in spontaneously diabetic congenic BB rats
Department of Clinical Sciences, Diabetes and Celiac Disease Unit, Lund University, Malmö, Sweden.
Umeå University, Faculty of Science and Technology, Department of Chemistry. (Computational Life Science Cluster (CLiC))
Department of Medicine, University of Washington, Seattle, WA, USA.
Umeå University, Faculty of Science and Technology, Department of Chemistry. (Computational Life Science Cluster, KBC)
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2011 (English)In: Metabolomics, ISSN 1573-3882, Vol. 7, no 4, 593-603 p.Article in journal (Refereed) Published
Abstract [en]

The clinical presentation of type 1 diabetes is preceded by a prodrome of beta cell autoimmunity. We probed the short period of subtle metabolic abnormalities, which precede the acute onset of diabetes in the spontaneously diabetic BB rat, by analyzing the serum metabolite profile detected with combined gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). We found that the metabolite pattern prior to diabetes included 17 metabolites, which differed between individual diabetes prone (DP) BB rats and their age and sex matched diabetes resistant (DR) littermates. As the metabolite signature at the 40 days of age baseline failed to distinguish DP from DR, there was a brief 10-day period after which the diabetes prediction pattern was observed, that includes fatty acids (e.g. oleamide), phospholipids (e.g. phosphocholines) and amino acids (e.g. isoleucine). It is concluded that distinct changes in the serum metabolite pattern predict type 1 diabetes and precede the appearance of insulitis in spontaneously diabetic BB DP rats. This observation should prove useful to dissect mechanisms of type 1 diabetes.

Place, publisher, year, edition, pages
Springer , 2011. Vol. 7, no 4, 593-603 p.
Keyword [en]
Type 1 diabetes, Metabolomics, OPLS-DA, Dynamic modeling
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:umu:diva-45744DOI: 10.1007/s11306-011-0278-3OAI: diva2:434718

Published online 29 January, 2011.

Available from: 2011-08-16 Created: 2011-08-16 Last updated: 2012-09-05

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Trygg, JohanMadsen, RasmusStenlund, Hans
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