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Continuous development of arrhythmia is observed in Swedish transplant patients with familial amyloidotic polyneuropathy (amyloidogenic transthyretin Val30Met variant)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Social Sciences, Department of Statistics.
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2011 (English)In: Liver transplantation, ISSN 1527-6465, E-ISSN 1527-6473, Vol. 17, no 2, 122-128 p.Article in journal (Refereed) Published
Abstract [en]

In patients with familial amyloidotic polyneuropathy (FAP), heart complications are prognostic factors for mortality and morbidity after liver transplantation (LT). However, only a few studies have analyzed the development of arrhythmia in transplant patients with FAP. We investigated the development of arrhythmia requiring pacemaker insertion (PMI) in Swedish transplant patients with FAP, and we related the findings to gender, age at disease onset, and survival. One hundred four transplant patients with the amyloidogenic transthyretin Val30Met mutation were included in the study. Twenty-six (25%) received a pacemaker during the observation period (a median of 11 years after disease onset). This frequency was comparable to that noted in a previous study describing the natural course of FAP. No significant differences in PMI between early-onset cases (<50 years old) and late-onset cases (≥ 50 years old) or between genders were observed. PMI was not significantly related to patient survival. Our study confirms our previously reported short-time observation: LT does not prevent the development of heart arrhythmia necessitating PMI. The development of arrhythmia is unrelated to gender or age at disease onset, and the yearly risk does not appear to decrease with time after LT.

Place, publisher, year, edition, pages
2011. Vol. 17, no 2, 122-128 p.
URN: urn:nbn:se:umu:diva-45878DOI: 10.1002/lt.22184PubMedID: 21280184OAI: diva2:435631
Available from: 2011-08-19 Created: 2011-08-19 Last updated: 2012-01-18Bibliographically approved

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Okamoto, SadahisaHörnsten, RolfWijayatunga, PriyanthaSuhr, Ole B
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MedicineDepartment of Statistics
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