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Serum markers are not reliable measures of renal function in conjunction with cardiopulmonary bypass
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology. (Kardiologi)
2011 (English)In: Interactive Cardiovascular and Thoracic Surgery, ISSN 1569-9293, E-ISSN 1569-9285, Vol. 12, no 5, 713-717 p.Article in journal (Refereed) Published
Abstract [en]

The present study explored the influence of haemodilution on estimates of the glomerular filtration rate (GFR) in conjunction with cardiopulmonary bypass (CPB) and cardiac surgery. Ninety-eight patients (n = 98) undergoing coronary artery bypass grafting with the aid of CPB were examined. The serum concentration of cystatin C and creatinine was analysed prior to surgery, after completion of CPB and in the intensive care the day after surgery. The estimated GFR was calculated using standard equations based on the serum concentration of cystatin C and creatinine. It was found that haemodilution induced by CPB had significant effects on the estimated GFR. For cystatin C, the GFR increased by 50.5 ± 2.5 ml/min (P = 0.000) and for creatinine based GFR with 22.5 ± 0.9 ml/min (P = 0.000) using the 4-variable modification of diet renal disease formula and with 22.1 ± 0.93 ml/min (P = 0.000) for the Cockcroft-Gault formula, respectively. Similar effects of haemodilution on GFR were also detected postoperatively. Haemodilution induced by CPB may therefore significantly overestimate the renal function as indicated by GFR based on serum markers.

Place, publisher, year, edition, pages
2011. Vol. 12, no 5, 713-717 p.
Keyword [en]
Renal function; Creatinine; Cystatin C; Cardiopulmonary bypass; Haemodilution
Identifiers
URN: urn:nbn:se:umu:diva-45882DOI: 10.1510/icvts.2010.259432PubMedID: 21297138OAI: oai:DiVA.org:umu-45882DiVA: diva2:435641
Available from: 2011-08-19 Created: 2011-08-19 Last updated: 2017-12-08Bibliographically approved

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Svenmarker, StaffanHäggmark, SörenHolmgren, AndersNäslund, Ulf
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